A recent study coauthored by GCDTR researchers and Jaeb Center for Health Research how inhaled Technosphere insulin (TI) performs in youth living with type 1 diabetes. The multicenter randomized study evaluated post-meal glucose responses in 217 children and adolescents (ages 4–17) using inhaled insulin during a standardized meal challenge, with outcomes compared to adults receiving inhaled or rapid-acting injectable insulin.
Key findings: • Lower post-meal glucose spikes: Youth using inhaled Technosphere insulin had significantly smaller glucose excursions compared with adults using rapid-acting injectable insulin. • Improved glycemic control metrics: The inhaled insulin group showed lower peak glucose levels and reduced glucose exposure over time (AUC).
• More time in target range: Participants experienced higher time-in-range (70–180 mg/dL) after meals. • Consistent effects across glycemic control groups: Results were similar regardless of baseline HbA1c levels. These findings suggest that ultra-rapid inhaled insulin may offer a promising strategy to better control post-meal glucose in children and adolescents with type 1 diabetes, addressing one of the most persistent challenges in diabetesmanagement.
