*Bold text indicates a member of the GCDTR
Liraglutide Hospital Discharge Trial: A Randomized Controlled Trial Comparing the Safety and Efficacy of Liraglutide versus Glargine Insulin for the Management of Patients with Type 2 Diabetes After Hospital Discharge
Francisco J. Pasquel, Maria A. Urrutia, Saumeth Cardona, K. Walkiria Zamudio Coronado, Bonnie Albury, M. Citlalli Perez-Guzman, Rodolfo J. Galindo ... Priyathama Vellanki, Maya Fayfman, Georgia M. Davis, Alexandra L. Migdal, Limin Peng, Guillermo E. Umpierrez
Diabetes, Obesity and Metabolism - 2021 Feb 16. Online ahead of print.
Few studies have focused on pharmacologic diabetes therapy adjustments at hospital discharge. This randomized clinical trial compared a GLP-1 receptor analog with basal insulin at hospital discharge in patients with uncontrolled type 2 diabetes.
Prevalence of and Factors Associated With Nurse Burnout in the US
Megha K. Shah, Nikhila Gandrakota, Jeannie P. Cimiotti, Neena Ghose, Miranda Moore, Mohammed K. Ali
JAMA Network Open - 2021 Feb 1;4(2):e2036469.
Clinician burnout is a major risk to the health of the US. Nurses make up most of the health care workforce, and estimating nursing burnout and associated factors is vital for addressing the causes of burnout. The objective was to measure rates of nurse burnout and examine factors associated with leaving or considering leaving employment owing to burnout.
Association Between Achieving Inpatient Glycemic Control and Clinical Outcomes in Hospitalized Patients With COVID-19: A Multicenter, Retrospective Hospital-Based Analysis
David C. Klonoff, Jordan C. Messler, Guillermo E. Umpierrez, Limin Peng, Robby Booth, Jennifer Crowe, Valerie Garrett, Raymie McFarland, Francisco J. Pasquel
Diabetes Care - 2021 Feb;44(2):578-585.
Diabetes and hyperglycemia are important risk factors for poor outcomes in hospitalized patients with coronavirus disease 2019 (COVID-19). The authors investigated whether achieving glycemic control soon after admission, in both intensive care unit (ICU) and non-ICU settings, could affect outcomes in patients with COVID-19.
Sitagliptin for the prevention and treatment of perioperative hyperglycaemia in patients with type 2 diabetes undergoing cardiac surgery: A randomized controlled trial
Saumeth Cardona, Katerina Tsegka, Francisco J. Pasquel, Sol Jacobs, Michael Halkos, W. Brent Keeling, Georgia M. Davis, Maya Fayfman, Bonnie Albury, Maria A. Urrutia, Rodolfo J. Galindo, Alexandra L. Migdal, Steven Macheers, Robert A. Guyton, Priyathama Vellanki, Limin Peng, Guillermo E. Umpierrez
Diabetes, Obesity and Metabolism - 2021 Feb;23(2):480-488.
The goal was assess whether treatment with sitagliptin, starting before surgery and continued during the hospital stay, can prevent and reduce the severity of perioperative hyperglycaemia in patients with type 2 diabetes undergoing coronary artery bypass graft (CABG) surgery.
Management of diabetes and hyperglycaemia in the hospital
Francisco J. Pasquel, M. Cecilia Lansang, Ketan Dhatariya, Guillermo E. Umpierrez
The Lancet Diabetes & Endocrinology - 2021 Mar;9(3):174-188.
This paper explores the respective efficacies of various forms of treating hyperlycaemia in the inpatient hospital setting, such as intravenous insulin therapy and oral antidiabetic medications.
Glycemic Monitoring and Management in Advanced Chronic Kidney Disease
Rodolfo J. Galindo, Roy W. Beck, Maria F. Scioscia, Guillermo E. Umpierrez, Katherine R. Tuttle
Endocrine Reviews - 2020 Oct 1;41(5):756-774.
This paper demonstrates that the advent of continuous glucose monitoring offers promise for more precise monitoring and treatment adjustments to permit fine-tuning of glycemic management in people with diabetes and advanced chronic kidney disease.
Reducing Inpatient Hypoglycemia in the General Wards Using Real-Time Continuous Glucose Monitoring: The Glucose Telemetry System, a Randomized Clinical Trial
Lakshmi G. Singh, Medha Satyarengga, Isabel Marcano, William H. Scott, Lillian F. Pinault, Zhaoyong Feng, John D. Sorkin, Guillermo E. Umpierrez, Elias K. Spanakis
Diabetes Care - 2020 Nov;43(11):2736-2743.
Use of real-time continuous glucose monitoring (RT-CGM) systems in the inpatient setting is considered investigational. The objective of this study was to evaluate whether RT-CGM, using the glucose telemetry system, can prevent hypoglycemia in the general wards.
Barriers to Diabetic Foot Care in a Disadvantaged Population: A Qualitative Assessment
Maya Fayfman, Marcos C. Schechter, Guillermo E. Umpierrez, et al.
Journal of Diabetes and its Complications - 2020 Dec;34(12):107688.
The authors explored barriers to proper foot care in this population using a qualitative approach with focus group discussions (FGD).
Comparison of the FreeStyle Libre Pro Flash Continuous Glucose Monitoring (CGM) System and Point-of-Care Capillary Glucose Testing (POC) in Hospitalized Patients With Type 2 Diabetes (T2D) Treated With Basal-Bolus Insulin Regimen
Rodolfo Galindo, Alexandra L. Migdal, Georgia M. Davis, Maria A. Urrutia, Bonnie Albury, Cesar Zambrano, Priyathama Vellanki, Francisco J. Pasquel, Maya Fayfman, Limin Peng, Guillermo E. Umpierrez
Diabetes Care - 2020 Nov;43(11):2730-2735.
The authors compared the performance of the FreeStyle Libre Pro continuous glucose monitoring (CGM) and point-of-care capillary glucose testing (POC) among insulin-treated hospitalized patients with type 2 diabetes (T2D).
Preparedness cycle to address transitions in diabetes care during the COVID-19 pandemic and future outbreaks
Unjali P. Gujral, Leslie Johnson, Jannie Nielsen, Priyathama Vellanki, J. Sonya Haw, Georgia M. Davis, Mary Beth Weber, Francisco J. Pasquel
BMJ Open Diabetes Research & Care - 2020 Jul;8(1):e001520.
The authors describe how to respond to the public health crisis focused on diabetes care in the USA. They present strategies to address and evaluate transitions in diabetes care occurring in the immediate short-term (ie, response and mitigation), as well as phases to adapt and enhance diabetes care during the months and years to come while also preparing for future pandemics (ie, recovery, surveillance, and preparedness).
Incidence of diabetes and prediabetes and predictors of glycemic change among South Asians in the USA: The MASALA study
Unjali P. Gujral, K.M. Venkat Narayan, Namratha R. Kandula, Kiang Liu, Alka M. Kanaya
BMJ Open Diabetes Research & Care - 2020 Jul;8(1):e001063.
There is a paucity of data on prediabetes and T2DM incidence and related predictors in South Asians in the USA. The authors assessed the incidence of various categories of dysglycemia including isolated impaired fasting glucose (iIFG), isolated impaired glucose tolerance (iIGT), combined impaired fasting glucose and impaired glucose tolerance (IFG+IGT) and T2DM as well as correlates of glycemic progression in this group.
Implementation of Continuous Glucose Monitoring in the Hospital: Emergent Considerations for Remote Glucose Monitoring During the COVID-19 Pandemic
Rodolfo J. Galindo, Guillermo E. Umpierrez, Georgia M. Davis, Francisco J. Pasquel, Priya Vellanki, et al.
Journal of Diabetes Science and Technology - 2020 Jul;14(4):822-832.
In this commentary, the authors analyze the answers to six questions about what is needed to bring CGM into the hospital as a reliable, safe, and effective tool, especially with regard to those patients with COVID-19.
Physical fitness and activity changes after a 24-week soccer-based adaptation of the U.S diabetes prevention program intervention in Hispanic men
Jennifer K. Frediani, Alan F. Bienvenida, Jianheng Li, Melinda K. Higgins, Felipe Lobelo
Progress in Cardiovascular Diseases - Nov-Dec 2020;63(6):775-785.
The purpose of this study was to determine the effects of an exercise intervention implementing the Center for Disease Control and Prevention National Diabetes Prevention Program plus recreational soccer in Hispanic men.
Population insulin sensitivity from sparsely sampled oral glucose tolerance tests
Darko Stefanovski, Priyathama Vellanki, Dawn D. Smiley-Byrd, Guillermo E. Umpierrez, Raymond C. Boston
Metabolism - 2020 Sep;110:154298.
This work aimed to estimate population-level insulin sensitivity from 2-hour oral glucose tolerance tests with less than 7 samples.
A Randomized Controlled Trial Comparing Glargine U300 and Glargine U100 for the Inpatient Management of Medicine and Surgery Patients With Type 2 Diabetes: Glargine U300 Hospital Trial
Francisco J. Pasquel, M. Cecilia Lansang, Ameer Khowaja, M. Augustina Urrutia, Saumeth Cardona, Bonnie Albury, Rodolfo J. Galindo, Maya Fayfman, Georgia Davis, Alexandra Migdal, Priyathama Vellanki, Limin Peng, Guillermo E. Umpierrez
Diabetes Care - 2020 Jun;43(6):1242-1248.
The role of U300 glargine insulin for the inpatient management of type 2 diabetes (T2D) has not been determined. The authors compared the safety and efficacy of glargine U300 versus glargine U100 in noncritically ill patients with T2D.
Alternative type 2 diabetes screening tests may reduce the number of U.S. adults with undiagnosed diabetes
R. S. Dadwani, M.R. Skandari, M.S. GoodSmith, L.S. Phillips, M.K. Rhee, N. Laiteerapong
Diabetic Medicine - 2020 Nov;37(11):1935-1943.
The aim was to evaluate the U.S. population-level impact of two alternatives for initial type 2 diabetes screening compared with American Diabetes Association-recommended tests.
Ketan K. Dhatariya, Nicole S. Glaser, Ethel Codner, Guillermo E. Umpierrez
Nature Reviews: Disease Primers - 2020 May 14;6(1):40.
In this primer, the authors discuss the epidemiology, pathogenesis, risk factors and diagnosis of diabetic ketoacidosis (DKA) and provide practical recommendations for the management of DKA in adults and children.
Long-term changes in carbohydrate tolerance, insulin secretion and action in African-American patients with obesity and history of hyperglycemic crises
Priyathama Vellanki, Darko Stefanovski, Isabel I. Anzola, Dawn D. Smiley, Limin Peng, Guillermo E. Umpierrez
BMJ Open Diabetes Research & Care - 2020 May;8(1):e001062.
Many African-Americans with obesity with newly diagnosed diabetes presenting with diabetic ketoacidosis or severe hyperglycemia discontinue insulin therapy and achieve near-normoglycemia remission and able to be managed on oral antidiabetic agents during follow-up. Using combined data from two randomized controlled trials, the authors assessed long-term carbohydrate tolerance and changes in insulin sensitivity and insulin secretion.
Association of glucose variability at the last day of hospitalization with 30-day readmission in adults with diabetes
Elias K. Spanakis, Lakshmi G. Singh, Tariq Siddiqui, John D. Sorkin, George Notas, Michelle F. Magee, Jeffrey C. Fink, Min Zhan, Guillermo E. Umpierrez
BMJ Open Diabetes Research & Care - 2020 May;8(1):e000990.
The objective was to evaluate whether increased glucose variability during the last day of inpatient stay is associated with increased risk of 30-day readmission in patients with diabetes.
Safety and efficacy of DDP4-inhibitors for management of hospitalized general medicine and surgery patients with type 2 diabetes
Cristina Lorenzo-González, Elena Atienza-Sánchez, David Reyes-Umpierrez, Priyathama Vellanki, Georgia M. Davis, Francisco J. Pasquel, Saumeth Cardona, Maya Fayfman, Limin Peng, Guillermo E. Umpierrez
Endocrine Practice - 2020 Apr 27. Online ahead of print.
DPP4-inhibitors (DPP4-i) have been shown to be effective for the management of inpatient diabetes. The authors report pooled data from three prospective studies using DPP4-i in general medicine and surgery patients with type 2 diabetes (T2D).
Tailoring lifestyle programmes for diabetes prevention for US South Asians
Mary Beth Weber, Monique M. Hennink, K.M. Venkat Narayan
Family Medicine and Community Health - 2020 Apr 1;8(2):e000295.
The purpose of this study was to develop and test the feasibility of a culturally tailored Diabetes Prevention Programme (DPP) for US South Asians, a large population with high diabetes risk.
Why are South Asians prone to type 2 diabetes? A hypothesis based on underexplored pathways
K.M. Venkat Narayan, Alka M. Kanaya
Diabetologia - 2020 Jun;63(6):1103-1109.
South Asians have a high prevalence of type 2 diabetes, even at a lower BMI. This review sets out the authors' perspective and hypothesis on the reasons for this.
Diabetes Technology in the Inpatient Setting for Management of Hyperglycemia
Endocrinology and Metabolism Clinics of North America - 2020 Mar;49(1):79-93.
The authors review current available diabetes technology as it relates to the management of hospitalized patients.
Emerging Trends and the Clinical Impact of Food Insecurity in Patients with Diabetes
Kristen L. Flint, Georgia M. Davis, Guillermo E. Umpierrez
Journal of Diabetes - 2020 Mar;12(3):187-196.
This review article explores the literature over the past 10 years pertaining to the complex relationship between food insecurity, social determinants of health, and chronic disease with an emphasis on diabetes and glycemic control.
Clinical Outcomes in Patients With Isolated or Combined Diabetic Ketoacidosis and Hyperosmolar Hyperglycemic State: A Retrospective, Hospital-Based Cohort Study
Francisco J. Pasquel, Katerina Tsegka, Heqiong Wang, Saumeth Cardona, Rodolfo J. Galindo, Maya Fayfman, Georgia Davis, Priyathama Vellanki, Alexandra Migdal, Unjali Gujral, K.M. Venkat Narayan, Guillermo E. Umpierrez
Diabetes Care - 2020 Feb;43(2):349-357.
The authors investigated hospital outcomes in patients with isolated or combined hyperglycemic crises.
Evaluation of a comprehensive diabetic foot ulcer care quality model
Marcos C. Schechter, Maya Fayfman, L.S.M.F. Khan, K. Carr, S. Patterson, David C. Ziemer, Guillermo E. Umpierrez, Ravi Rajani, Russell R. Kempker
Journal of Diabetes and Its Complications - 2020 Jan 2:107516.
Diabetes-related amputations are typically preceded by a diabetic foot ulcer (DFU) but models to assess the quality of care are lacking. The authors investigated a model to measure inpatient and outpatient quality.
Clinical utility of 30-minutes Plasma Glucose for prediction of Type 2 Diabetes among People with Prediabetes: Ancillary analysis of the Diabetes Community Lifestyle Improvement Program
Ram Jagannathan, Mary Beth Weber, Ranjit M. Anjana, Harish Ranjani, Lisa R. Staimez, Mohammed K. Ali, Viswanathan Mohan, K.M. Venkat Narayan
Diabetes Research and Clinical Practice - 2020 Feb 11;161:108075.
The aims were to examine the clinical utility of 30-min plasma glucose (30-min-PG) measurement during an oral glucose tolerance (OGTT) in predicting type 2 diabetes (T2DM).
Trends in Lifestyle Counseling for Adults With and Without Diabetes in the U.S., 2005–2015
Megha K. Shah, Miranda A. Moore, K.M. Venkat Narayan, Mohammed K. Ali
American Journal of Preventive Medicine - 2019 Nov;57(5):e153-e161.
Data from the 2005-2015 National Ambulatory Medical Care Surveys were used to assess trends in provider-reported diet or exercise counseling during ambulatory care visits.
Cardiovascular risk and the implications for clinical practice of cardiovascular outcome trials in type 2 diabetes
Robert J. Chilton, Kathleen M. Dungan, Jay H. Shubrook, Guillermo E. Umpierrez
Primary Care Diabetes - 2019 Nov 5. pii: S1751-9918(19)30075-0.
This review examines the impact of cardiovascular outcome trials (CVOTs) on clinical practice.
Impact of mismatches in HbA1c vs glucose values on the diagnostic classification of diabetes and prediabetes
A. Gonzalez, Y. Deng, A.N. Lane, D. Benkeser, X. Cui, L.R. Staimez, C.N. Ford, F. N. Khan, S.C. Markley Webster, A. Leong, P.W.F. Wilson, L.S. Phillips, M.K. Rhee
Diabetic Medicine - 2019 Nov 13.
The aims were to determine whether HbA1c mismatches (HbA1c levels that are higher or lower than expected for the average glucose levels in different individuals) could lead to errors if diagnostic classification is based only on HbA1c levels.
Continuous Glucose Monitoring in General Wards for Prevention of Hypoglycemia: Results From the Glucose Telemetry System Pilot Study
Lakshmi G. Singh, David L. Levitt, Medha Satyarengga, Lillian Pinault, Min Zhan, John D. Sorkin, Jeffrey C. Fink, Guillermo E. Umpierrez, Elias K. Spanakis
Journal of Diabetes Science and Technology - 2019 Nov 28:1932296819889640.
In this pilot study the authors evaluated the use of the glucose telemetry system (GTS) using CGM technology and remote monitoring to prevent inpatient hypoglycemia in high-risk insulin-treated patients with type 2 diabetes (DM2).
Hospital Admissions for Hyperglycemic Emergencies in Young Adults at an Inner-City Hospital
Rachel A Wolf, J. Sonya Haw, Sudeshna Paul, Melissa Spezia Faulkner, EunSeok Cha, MK Findley, Farah Khan, Sara Markley Webster, Anastasia-Stefania Alexopoulos, Komal Mehta, David A Alfa, Mohammed K. Ali
Diabetes Research and Clinical Practice - 2019 Nov;157:107869.
The study aims were to examine associations of patient-level characteristics with hyperglycemic emergency hospitalization and to identify variations based on diabetes type and glycemic control.
Sitagliptin for the prevention of stress hyperglycemia in patients without diabetes undergoing coronary artery bypass graft (CABG) surgery
Saumeth Cardona, Katerina Tsegka, Francisco J Pasquel, Maya Fayfman, Limin Peng, Sol Jacobs, Priyathama Vellanki, Michael Halkos, Robert A Guyton, Vinod H Thourani, Rodolfo J Galindo, Guillermo Umpierrez
BMJ Open Diabetes Research & Care - 2019 Sep 3;7(1):e000703.
This paper aims to determine if treatment with sitagliptin, a dipeptidyl peptidase-4 inhibitor, can prevent stress hyperglycemia in patients without diabetes undergoing coronary artery bypass graft (CABG) surgery.
Association of Glucose Concentrations at Hospital Discharge With Readmissions and Mortality: A Nationwide Cohort Study
Elias K. Spanakis, Guillermo E. Umpierrez, Tariq Siddiqui, Min Zhan, Soren Snitker, Jeffrey C. Fink, John D. Sorkin
The Journal of Clinical Endocrinology and Metabolism - 2019 Sep 1;104(9):3679-3691.
The authors seek to investigate whether patients with diabetes and low glucose values during the last day of hospitalization are at increased risk of readmission or mortality.
Random plasma glucose predicts the diagnosis of diabetes
Mary K. Rhee, Lisa R. Staimez, Christopher N. Ford, Peter W. F. Wilson, Lawrence S. Phillips, et al.
PLoS One - 2019 Jul 19;14(7):e0219964.
The authors sought to determine whether routinely available outpatient random plasma glucose (RPG) would be useful to facilitate the diagnosis of diabetes.
Debate on Insulin vs Non-insulin Use in the Hospital Setting—Is It Time to Revise the Guidelines for the Management of Inpatient Diabetes?
Francisco J. Pasquel, Maya Fayfman, Guillermo E. Umpierrez
Current Diabetes Reports - 2019 Jul 29;19(9):65.
This review summarizes recent evidence from observational studies and clinical trials suggesting that not all patients require treatment with complex insulin regimens.
Efficacy and safety of linagliptin to improve glucose control in older people with type 2 diabetes on stable insulin therapy: A randomized trial
Gilbert Ledesma, Guillermo E. Umpierrez, John E. Morley, Diane Lewis‐D'Agostino, Annett Keller, Thomas Meinicke, Sandra van der Walt, et al.
Diabetes, Obesity and Metabolism - 2019 Jul 12.
The aim was to assess the addition of linagliptin as an alternative to insulin uptitration in older people with type 2 diabetes on stable insulin therapy.
Isolated HbA1c identifies a different subgroup of individuals with type 2 diabetes compared to fasting or post-challenge glucose in Asian Indians: The CARRS and MASALA studies
Unjali P. Gujral, Dorairaj Prabhakaran, K.M. Venkat Narayan, et al.
Diabetes Research and Clinical Practice - 2019 Jul;153:93-102.
The authors assess the accuracy of hemoglobin A1c in diagnosing type 2 diabetes in populations from Chennai and Delhi vs. ethnic Indians from the U.S.
Team-Based Care to Improve Diabetes Management: A Community Guide Meta-analysis
Timothy W. Levengood, Yinan Peng, Ka Zang Xiong, Ziwei Song, Randy Elder, Mohammed K. Ali, Marshall H. Chin, et al.
American Journal of Preventive Medicine - 2019 Jul;57(1):e17-e26.
The authors perform a review of 35 studies assessing team-based care for managing diabetes.
Efficacy and Safety of Iglarlixi in Hispanics and Non-Hispanic Whites with Type 2 Diabetes
Pablo F. Mora, Jason Chao, Aramesh Saremi, Terry A. Dex, Michelle Roberts, Guillermo E. Umpierrez
Endocrine Practice - 2019 Jun 26.
The efficacy and safety of insulin glargine 100 units/mL (iGlar) and the fixed-ratio combination of iGlar and the glucagon-like peptide-1 receptor agonist lixisenatide (iGlarLixi) was assessed in Hispanic and non-Hispanic white patients with type 2 diabetes from 25 countries.
Racial differences in performance of HbA1c for the classification of diabetes and prediabetes among US adults of non-Hispanic black and white race
Christoher N. Ford, Mary K. Rhee, Sandra L. Jackson, Peter W. F. Wilson, Lawrence S. Phillips, Lisa R. Staimez, et al.
Diabetic Medicine - 2019 Jun 12.
The authors characterize differences between black and white people in optimal HbA1c thresholds for diagnoses of diabetes and prediabetes.
Tale of two Indians: Heterogeneity in type 2 diabetes pathophysiology
Lisa R. Staimez, Mohan Deepa, Mohammed K. Ali, Viswanathan Mohan, Robert L. Hanson, K.M. Venkat Narayan
Diabetes/Metabolism Research and Reviews - 2019 May 30:e3192.
The authors examine insulin secretion and insulin resistance across two ethnicities with particularly high risk for diabetes yet with widely different distributions of weight class.
Reach and Use of Diabetes Prevention Services in the United States, 2016-2017
Mohammed K. Ali, Kai McKeever Bullard, Giuseppina Imperatore, et al.
JAMA Network Open - 2019 May 3;2(5):e193160.
A status report is provided on the reach and use of diabetes prevention services nationally.
A Multilevel Intervention With African American Churches to Enhance Adoption of Point-of-Care HIV and Diabetes Testing, 2014–2018
Gina M. Wingood, Danielle Lambert, Tiffaney Renfro, Mohammed Ali, Ralph Joseph DiClemente
American Journal of Public Health - 2019 Feb.
The authors describe a multilevel intervention to enhance adoption of point-of-care HIV and diabetes testing at church health fairs in Atlanta, Georgia.
Diabetes Mellitus-Related All-Cause and Cardiovascular Mortality in a National Cohort of Adults
Sridharan Raghavan, Peter W. F. Wilson, Lawrence S. Phillips, et al.
Journal of the American Heart Association - 2019 Feb 19;8(4):e011295.
The authors reassess diabetes mellitus-related mortality in individuals receiving routine care in the United States in the contemporary era of CVD risk reduction.
When Basal Insulin is Not Enough: A Dose Response Relationship Between Insulin Glargine 100 Units/mL (U100) and Glycemic Control
Guillermo E. Umpierrez, Neil Skolnik, Terry Dex, Louise Traylor, Jason Chao, Charles Shaefer
Diabetes, Obesity and Metabolism - 2019 Feb 5.
In this post-hoc analysis, the authors construct a clinical response curve for basal insulin, assessing the impact of increasing doses on glycemic measures, body weight, and hypoglycemia.
A Randomized Controlled Trial on the Safety and Efficacy of Exenatide Therapy for the Inpatient Management of General Medicine and Surgery Patients With Type 2 Diabetes
Maya Fayfman, Rodolfo J. Galindo, Daniel J. Rubin, et al.
Diabetes Care - 2019 Jan 24.
This multicenter, open-label, randomized trial examines the safety and efficacy of exenatide alone or in combination with basal insulin in non–critically ill patients with type 2 diabetes (T2D).
Clinical characteristics and outcomes of symptomatic and asymptomatic hypoglycemia in hospitalized patients with diabetes
Saumeth Cardona, Patricia C. Gomez, Priyathama Vellanki, et al.
BMJ Open Diabetes Research and Care - 2018 Dec 18;6(1):e000607.
The authors determine the clinical characteristics and hospital outcomes of general medicine and surgery patients with symptomatic and asymptomatic hypoglycemia.
Predicting diabetes risk among HIV-positive and HIV-negative women: an assessment of the ADA and FINRISC diabetes risk scores
Karla I. Galaviz, Michael F. Schneider, Phyllis Tien, et al.
AIDS. 2018 Nov 28;32(18):2767-2775.
The authors assess the performance of an adapted American Diabetes Association (ADA) risk score and the concise Finnish Diabetes Risk Score (FINRISC) for predicting type 2 diabetes in women with and at risk of HIV infection.
Glycaemic Efficacy and Safety of Linagliptin compared to Basal-Bolus Insulin Regimen in Patients with Type 2 Diabetes Undergoing Non-Cardiac Surgery: A Multicenter Randomized Clinical Trial
Priyathama Vellanki, Neda Rasouli, David Baldwin, et al.
Diabetes, Obesity and Metabolism - 2018 Nov 20.
The use of incretin-based therapy instead of or complementary to insulin therapy is an active area of research in hospitalized patients with type 2 diabetes (T2D). Here, the authors determine glycaemic efficacy and safety of linagliptin compared to basal-bolus insulin regimen in hospitalized surgical patients with T2D.
Advancing Health Policy and Program Research in Diabetes: Findings from the Natural Experiments for Translation in Diabetes (NEXT-D) Network
Mohammed K. Ali, Frank Wharam, O. Kenrik Duru, et al.
Current Diabetes Reports - 2018 Nov 20;18(12):146.
To advance understanding of the impacts of policies and programs aimed at improving detection, engagement, prevention, and clinical diabetes management in the USA, the authors synthesize findings from a network of studies that use natural experiments to evaluate diabetes health policies and programs.
Self-Efficacy and Diabetes Prevention in Overweight South Asians with Prediabetes
Catherine E. Cioffi, Harish Ranjani, Lisa R. Staimez, Ranjit Mohan Anjana, Viswanathan Mohan, Mary Beth Weber
BMJ Open Diabetes Research & Care - 2018 Oct 15;6(1):e000561
The authors evaluated the effects of a diabetes prevention intervention on self-efficacy (SE) and the associations between SE and diabetes-related outcomes among overweight Asian Indian adults with pre-diabetes in a randomized controlled translational trial (the Diabetes Community Lifestyle Improvement Program, D-CLIP).
Safety and Efficacy of DPP4 Inhibitor and Basal Insulin in Type 2 Diabetes: An Updated Review and Challenging Clinical Scenarios
Fernando Gomez-Peralta, Cristina Abreu, Sara Gomez-Rodriguez, Rafael J. Barranco, and Guillermo E. Umpierrez
Diabetes Therapy - 2018 Oct;9(5):1775-1789
The present review summarizes the extensive evidence on the combination therapy of DPP4 inhibitors and insulin-based regimens in patients with type 2 diabetes. The authors focus their discussion on challenging clinical scenarios including patients with chronic renal impairment, elderly persons and hospitalized patients.
Cost-Effectiveness of a Faith-Based Lifestyle Intervention for Diabetes Prevention among African Americans: A Within-Trial Analysis
Elizabeth C. Rhodes, Eeshwar K. Chandrasekar, Shivani A. Patel, K.M. Venkat Narayan, Thomas V. Joshua, Lovoria B. Williams, Lucy Marion, and Mohammed K. Ali
Diabetes Research and Clinical Practice - 2018 Sep 28;146:85-92
The authors assessed costs and cost-effectiveness of implementing Fit Body and Soul (FBAS), a church-based 18-session lifestyle education intervention for African Americans.
Ethnic Differences in the Prevalence of Diabetes in Underweight and Normal Weight Individuals: The CARRS and NHANES Studies
Unjali P. Gujral, Viswanathan Mohan, Rajendra Pradeepa, Mohan Deepa, Ranjit Mohan Anjana, and K.M. Venkat Narayan
Diabetes Research and Clinical Practice - 2018 Sep 20;146:34-40
Type 2 diabetes in lean individuals has recently come to attention. The assessed type 2 diabetes prevalence and the associated risk factors in underweight and normal weight individuals in two ethnic populations.
Advancing Measurement of Diabetes at the Population Level
Mohammed K. Ali, Karen R. Siegel, Michael Laxy, and Edward W. Gregg
Current Diabetes Reports - 2018 Sep 19;18(11):108
To provide a critical reflection on current diabetes surveillance, the authors provide in-depth discussion about how upstream determinants, prevalence, incidence, and downstream impacts of diabetes are measured in the USA, and the challenges in obtaining valid, accurate, and precise estimates.
Sitagliptin for prevention of stress hyperglycemia in patients without diabetes undergoing general surgery: A pilot randomized study
Maya Fayfman, Georgia Davis, Elizabeth W. Duggan, Maria Urrutia, David Chachkhiani, Joanna Schindler, Francisco J. Pasquel, Rodolfo J. Galindo, Priyathama Vellanki, David Reyes-Umpierrez, Heqiong Wang, and Guillermo E. Umpierrez
Journal of Diabetes and its Complications - 2018 Sep 1. pii: S1056-8727(18)30752-9
The authors investigated if a dipeptidyl peptidase-4 inhibitor, sitagliptin, can prevent perioperative stress hyperglycemia in patients without prior history of diabetes mellitus undergoing general surgery.
Diabetes Among Non-Overweight Individuals: an Emerging Public Health Challenge
Unjali P. Gujral, Mary Beth Weber, Lisa R. Staimez, and K.M. Venkat Narayan
Current Diabetes Reports - 2018 Jul:18(8):60
In this review, the authors discuss the epidemiology of type 2 diabetes in non-overweight adults; pose questions about etiology, pathophysiology, diagnosis, and prognosis; and examine implications for prevention and treatment.
Global Diabetes Prevention Interventions: A Systematic Review and Network Meta-analysis of the Real-World Impact on Incidence, Weight, and Glucose
Karla Ivette Galaviz, Mary Beth Weber, Audrey Straus, Jeehea Sonya Haw, K.M. Venkat Narayan, and Mohammed Kumail Ali
Diabetes Care - 2018 Jul;41(7):1526-1534
The purpose of this study was to synthesize global evidence on the impact of lifestyle modification (LSM) strategies on diabetes incidence and risk factors in one parsimonious model.
The Efficacy and Safety of Co-Administration of Sitagliptin with Metformin in Patients with Type 2 Diabetes at Hospital Discharge
Roma Y. Gianchandani, Francisco J. Pasquel, Daniel J. Rubin, Kathleen M. Dungan, Priyathama Vellanki, Heqiong Wang, Isabel Anzola, Patricia Gomez, Israel Hodish, Sangeeta Lathkar-Pradhan, Jennifer Iyengar, and Guillermo E. Umpierrez
Endocrine Practice - 2018 Jun;24(6):556-564
Few randomized controlled trials have focused on the optimal management of patients with type 2 diabetes (T2D) during the transition from the inpatient to outpatient setting. This multicenter open-label study explored a discharge strategy based on admission hemoglobin A1c (HbA1c) to guide therapy in general medicine and surgery patients with T2D.
Room for Improvement: The HIV–Diabetes Care Continuum Over 15 Years in the Women’s Interagency HIV Study
Jonathan Colasanti, Karla I. Galaviz, C. Christina Mehta, Kartika Palar, Michael F. Schneider, Phyllis Tien, Adaora A. Adimora, et al.
Open Forum Infectious Diseases - 2018 May;5(6)
The authors analyzed cross-sectional data of the Women's Interagency HIV Study (WIHS) from 2001, 2006, and 2015. They estimated the proportions of HIV-positive and HIV-negative women with diabetes who were engaged in care and achieved treatment goals and viral suppression.
A Randomized Controlled Study Comparing a DPP4 Inhibitor (Linagliptin) and Basal Insulin (Glargine) in Patients With Type 2 Diabetes in Long-term Care and Skilled Nursing Facilities: Linagliptin-LTC Trial
Guillermo E. Umpierrez, Saumeth Cardona, David Chachkhiani, Maya Fayfman, Sahebi Saiyed, Heqiong Wang, Priyathama Vellanki, et al.
Journal of the American Medical Directors Association - 2018 May;19(5):399-404
This 6-month open-label randomized controlled trial compared the efficacy and safety of a DPP4 inhibitor (linagliptin) and basal insulin (glargine) in LTC residents with T2DM.
Are the U.S. Territories Lagging Behind in Diabetes Care Practices?
Rachel P. Ogilvie, Shivani A. Patel, K.M. Venkat Narayan, Neil K. Mehta
Primary Care Diabetes - 2018 May;pii:S1751-9918
The authors compare the prevalence and secular trends of four recommended diabetes care practices in the U.S. territories of Guam, Puerto Rico, and the U.S. Virgin Islands to the 50 United States and D.C. ("U.S. States") in 2001-2015.
Dietary Behaviors and Glucose Metabolism in Young Adults at Risk for Type 2 Diabetes
EunSeok Cha, Sudeshna Paul, Betty J. Braxter, Guillermo Umpierrez, Melissa Spezia Faulkner
The Diabetes Educator - 2018 Apr;44(2):158-167
The purpose of the study was to examine the associations between dietary behaviors and glucose metabolism in high-risk young adults to increase the precision of nutrition education to prevent early onset type 2 diabetes (T2D).
The Effect of Continuous Glucose Mointoring in Preventing Inpatient Hypoglycemia in General Wards: The Glucose Telemtery System
Elias K. Spanakis, David L. Levitt, Tariq Siddiqui, Lakshmi G. Singh, Lillian Pinault, John Sorkin, Guillermo E. Umpierrez, Jeffrey C. Fink
Journal of Diabetes Science and Technology - 2018 Jan;12(1):20-25
The aim of this pilot study was to examine whether CGM readings can be successfully transmitted from the bedside to a central monitoring device in the nursing station, and whether a glucose telemetry system can prevent hypoglycemic events.
Declines in the Incidence of Diabetes in the U.S.: Real Progress or Artifact?
Elizabeth Selvin, Mohammed K. Ali
Diabetes Care - 2017 Sep;40(9):1139-1143
The authors present and discuss data that suggest improved detection and changes in screening and diagnostic practices may have resulted in the depletion of the "susceptible population."
Perioperative Hyperglycemia Management: An Update
Elizabeth W. Duggan, Karen Carlson, Guillermo E. Umpierrez
Anesthesiology - 2017 Mar;126(3):547-560
An association between perioperative hyperglycemia and adverse outcomes has been established in surgical patients, with morbidity being reduced in those treated with insulin. Here, a practical treatment algorithm and literature summary is provided for surgical patients with diabetes and hyperglycemia.
A National Effort to Prevent Type 2 Diabetes: Participant-Level Evaluation of CDC’s National Diabetes Prevention Program
Elizabeth K. Ely, Stephanie M. Gruss, Elizabeth T. Luman, Edward W. Gregg, Mohammed K. Ali, Kunthea Nhim, Deborah B. Rolka, Ann L. Albright
Diabetes Care - 2017 Oct; 40(10):1331-1341
This paper assesses participant-level results from the first 4 years of implementation of the National Diabetes Prevention Program (National DPP), a national effort to prevent type 2 diabetes in those at risk through structured lifestyle change programs.